Signature Medicine
Verified listingAbout Signature Medicine
What is Signature Medicine?
Signature Medicine is a concierge internal medicine practice in Newtown, PA, founded in 2005 by Dr. Ashish Sitapara. The practice describes itself as locally physician-owned. The listed prescriber is Ashish Sitapara, MD, FACP, who is board certified in internal medicine and a Fellow of the American College of Physicians. It has one office at 770 Newtown Yardley Rd, Ste 220a, Newtown, PA 18940, and the phone number is (215) 968-4804.
The practice offers six care pathways: Preventive & Longevity, Weight Management, Women's Health, Men's Health, Urgent & Same-Day, and Hospital Advocacy. Its weight management pathway includes GLP-1 prescribing with Ozempic, Wegovy, Zepbound, and Mounjaro, which are semaglutide and tirzepatide, along with baseline labs and an InBody body-composition scan. Men's health includes testosterone replacement therapy when a complete workup indicates it. The practice caps each physician's panel at 350 patients and lists visits of 30 to 60 minutes. It advertises 24/7 direct access by call, text, or email. It has a 5.0 Google rating from 80 reviews.
What does it cost?
It does not publish prices or the membership fee. The first consultation is complimentary. The practice accepts insurance. Its annual membership fee covers enhanced access and coordination services, while office visits, labs, and procedures are billed to insurance as usual. In its own words: "No surprise bills. No nickel-and-diming." The practice says medications are billed separately from membership, either to insurance or out of pocket, and that it helps with prior authorization. It does not publish those medication prices, and it does not say whether a cancellation policy applies.
What should you ask before you book?
Ask for the annual membership fee in writing, and whether it covers any medication. Ask what a GLP-1 prescription would cost you if insurance denies coverage. The practice names brand-name drugs, so ask whether it also offers compounded versions. Ask what follow-up visits, lab work, and InBody scans cost beyond what insurance pays. Ask whether virtual visits are offered, since it does not say. Ask how membership is canceled and whether any fee is refundable. Ask for office hours, which it does not list. Finally, confirm whether Dr. Sitapara writes every prescription himself or whether another clinician signs some of them.
Who is it a good fit for?
This is a good fit if you want one physician to coordinate prescriptions, labs, and specialist referrals over time, and you can pay an annual membership on top of insurance-billed care and separately billed medication. It is a weaker fit if you need to see prices before you book, since none are published.
Sources: signaturemedicinemd.com, signaturemedicinemd.com/membership/weight-management, signaturemedicinemd.com/membership/mens-health-testosterone
Services Offered
What we confirmed
Read off Signature Medicine’s own website on 2026-10-12. These are their words, not ours.
- ✓Medical weight loss — listed on their site as “GLP-1 prescribing (semaglutide / tirzepatide) for members who meet indications” source
- ✓Hormone therapy — listed on their site as “Signature Medicine prescribes testosterone replacement therapy when indicated by a complete workup, with the cardiovascular, sleep, prostate, and longevity picture in the same chart.” source
- ✓Longevity / anti-aging — listed on their site as “Preventive & Longevity” source