Medspa 501
Verified listingAbout Medspa 501
What is Medspa 501?
Medspa 501 is a medical spa at 69 Knox Way, STE 108, in Chapel Hill, North Carolina. It calls itself a med spa for aesthetics and longevity medicine, and it describes its care as medical-led. Most of its listed services are cosmetic, including injectables and fillers, facial treatments, microneedling and PRF. Its medical services include medical weight loss with semaglutide or tirzepatide injections, hormone optimization, IV nutrient therapy and a membership program called 1Wellness, which includes a lab panel and a personalized medication protocol. In its own words: "Medical weight loss at Medspa 501 is a clinically supervised program designed to address the metabolic, hormonal, and lifestyle factors that contribute to weight gain."
The clinic does not name a prescriber, so ask who writes prescriptions before you book. It lists certifications from The Institute for Functional Medicine and 3x4 Genetics, and it has an on-site partnership with 501 Pharmacy for prescriptions. Its Google rating is 4.9 from 147 reviews. Hours are Monday through Friday, 9:00am to 5:00pm. The clinic serves Chapel Hill, Pittsboro, Carrboro and Briar Chapel.
This listing is for its Chapel Hill office at 69 Knox Way, STE 108.
What does it cost?
Medspa 501 does not publish prices for any service, including medical weight loss. It does not state a consultation fee, whether medication is included in a program's cost, or whether it accepts insurance. It does offer a 1Wellness membership and payment plans, so ask what each costs and what it covers. Its footer links to a refund and cancellation policy, which you should read before you pay anything.
What should you ask before you book?
Ask which licensed prescriber will review your health history and labs, and whether that person sees you before any medication is started. Ask whether the clinic offers telehealth or whether every visit happens in person, since the listed hours are weekdays only.
Ask whether the monthly fee includes the medication or whether the drug is billed separately. Ask if the semaglutide or tirzepatide is brand-name or compounded, and whether 501 Pharmacy fills it. Find out what the lab panel costs and how often it is repeated, and what follow-up visits cost. Ask whether there is a consultation fee, whether the clinic bills insurance, and whether it accepts HSA funds or financing. Finally, ask how you cancel a membership, what the refund terms are, and whether there is a minimum commitment.
Who is it a good fit for?
This is a good fit if you want medical weight loss, hormone care or IV therapy in the same office as aesthetic treatments, and you are ready to pay out of pocket with the prescriber, medication and cancellation terms confirmed in writing first. It may not suit you if you need a named prescriber or a published price before you call, since Medspa 501 publishes neither.
Sources: medspa501.com, medspa501.com/medspa-services/medical-weight-loss-in-chapel-hill-nc, medspa501.com/blog/category/Weight+Loss
Services Offered
What we confirmed
Read off Medspa 501’s own website on 2026-10-15. These are their words, not ours.
- ✓Medical weight loss — listed on their site as “Semaglutide Injections” source
- ✓Hormone therapy — listed on their site as “Hormone Optimization” source
- ✓Longevity / anti-aging — listed on their site as “Our approach combines longevity medicine and functional medicine to help you improve how you feel today while building a long-term strategy for your health.” source
We have not yet collected published prices or prescriber credentials for this clinic. When we do, they will appear here with a link to the page they came from — or a note saying the clinic publishes none, which is itself worth knowing. Call them for a price in the meantime.
Hours
Monday - Friday 9:00am - 5:00pm