The VitalityMatch Library
Guides & Comparisons
Honest, research-backed guides on GLP-1, TRT, peptides, and longevity medicine. We compare providers, explain costs, and help you make an informed decision — without the sales pitch.
Medical Weight Loss
Online vs. Local GLP-1 Provider: Which Is Right for You?
There are three ways to get a GLP-1 now, not two — telehealth from $99/mo, the manufacturer direct from $149, or a local clinic. What each one actually buys you, and how to pick.
How to Choose a GLP-1 Clinic: What to Ask Before You Sign Up
Six questions that separate credible medical weight loss clinics from thin med-spas — and what the answers should tell you.
What Does GLP-1 Actually Cost? A Complete Price Guide
Real published GLP-1 prices: $299–$449/mo for Zepbound and $349/mo for Wegovy direct from the manufacturers, $99–$548/mo through telehealth, and $50 for eligible Medicare patients. Every figure below traces to a published source.
Best Weight Loss Telehealth Platforms: Ranked & Compared
We compared Ro, Hims/Hers, Mochi Health, Henry Meds, and more on price, medication options, and patient experience. Here's who wins — and for whom.
Weight Loss Medications Explained: GLP-1s, How They Work, and What to Expect
How GLP-1s like Ozempic, Zepbound and the new oral options actually work, honest side effects, who qualifies, and what a realistic treatment arc looks like.
Semaglutide: What It Is, How It Works, and What It Costs
Semaglutide is the active ingredient in Ozempic and Wegovy. What it does, what the trials actually showed, what it costs in 2026, and where compounded versions now stand.
Tirzepatide: How It Works, What It Costs, and the Compounding Question
Tirzepatide is the active ingredient in Mounjaro and Zepbound, and it acts on two hormone receptors rather than one. What that changes, what the trials showed, and where compounded versions now stand.
Tirzepatide vs. Semaglutide: How They Differ and Which Works Better
In the only head-to-head trial, tirzepatide produced 20.2% weight loss against semaglutide's 13.7% over 72 weeks. Here is what that means, and the cases where semaglutide is still the better choice.
Hormone Therapy
What Does Testosterone Replacement Therapy (TRT) Actually Cost?
The complete price breakdown for TRT — injections vs. gels vs. pellets, online vs. local clinic, and what's included in the monthly fee.
Best Online TRT Providers: Male Excel vs. Hims vs. Hone Health vs. Maximus
Four major online TRT platforms, compared on price, protocol quality, medication formats, and who each one is actually best for.
Best Women's HRT Telehealth Providers in 2026: Midi vs. Winona vs. Alloy and More
Six menopause telehealth providers compared — insurance-based vs. cash-pay, published pricing, testosterone availability, and honest limitations.
Guide to Men's TRT: What Testosterone Therapy Is, How It Works, and What to Expect
What TRT is, how a real diagnosis works, delivery formats compared, honest side effects, and the monitoring schedule a good clinic follows.
Guide to Women's HRT: Menopause Hormone Therapy Explained
What menopause hormone therapy actually is: estrogen and progesterone, delivery formats, the WHI scare explained, risks, and who it's really for.
What Does Women's HRT Actually Cost? A Complete Price Guide
Real published HRT prices: $23–$149/mo cash-pay subscriptions vs. $150–$250 insurance-clinic visits, what drives cost, and the cheap-generic angle.
Peptide Therapy
Peptide Therapy: What It Is, What It Costs, and Where to Get It Safely
BPC-157, sermorelin, CJC-1295 — the beginner's guide to peptide therapy. What each peptide does, what you should expect to pay, and how to find a legitimate provider.
Best Peptide Therapy Telehealth Providers in 2026: Compared
Five vetted peptide telehealth providers compared on price, treatment menu, and physician oversight — with honest limitations for each.
Peptide Therapies Explained: What They Are, How They Work, and What's Actually Proven
What peptides actually are, the classes clinics sell, and an honest evidence spectrum — from FDA-approved to largely unproven — plus the regulatory reality.
Longevity & Anti-Aging
Lifeforce vs. AgelessRx vs. Tally Health: Which Longevity Platform Is Worth It?
Three very different approaches to longevity medicine — biomarker-driven programs, prescription-first platforms, and epigenetic age testing. Here's how to choose.
Longevity Supplements and Modalities Explained: What's Proven, What's Promising, What's Hype
An honest evidence grading of longevity supplements — omega-3, creatine, NMN, resveratrol, rapamycin — plus modalities, and why the basics beat them all.
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